diff --git a/pyinfra/queue/queue_manager.py b/pyinfra/queue/queue_manager.py
index 39383a7..b3bb425 100644
--- a/pyinfra/queue/queue_manager.py
+++ b/pyinfra/queue/queue_manager.py
@@ -112,8 +112,16 @@ class QueueManager(object):
     def _create_queue_callback(self, process_message_callback: Callable):
         def callback(_channel, frame, properties, body):
             self.logger.info(f"Received message from queue with delivery_tag {frame.delivery_tag}")
-            self.logger.debug(f"Processing {(frame, properties, body)}.")
 
+            # Only try to process each message once.
+            # Requeueing will be handled by the dead-letter-exchange.
+            # This prevents endless retries on messages that are impossible to process.
+            if frame.redelivered:
+                self.logger.info(f"Aborting message processing for delivery_tag {frame.delivery_tag} "
+                                 f"due to it being redelivered")
+                self._channel.basic_nack(frame.delivery_tag, requeue=False)
+
+            self.logger.debug(f"Processing {(frame, properties, body)}.")
             try:
                 unpacked_message_body = json.loads(body)